Module also offered within study programmes:
General information:
Name:
Nanomedicine
Course of study:
2017/2018
Code:
EIB-1-608-s
Faculty of:
Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering
Study level:
First-cycle studies
Specialty:
-
Field of study:
Biomedical Engineering
Semester:
6
Profile of education:
Academic (A)
Lecture language:
English
Form and type of study:
Full-time studies
Course homepage:
 
Responsible teacher:
prof. dr hab. inż. Pamuła Elżbieta (epamula@agh.edu.pl)
Academic teachers:
prof. dr hab. inż. Pamuła Elżbieta (epamula@agh.edu.pl)
dr inż. Krok-Borkowicz Małgorzata (krok@agh.edu.pl)
Module summary

Overview of nanomedicine; impact of nanotechnology on healthcare; application of nanotechnology in drug delivery, biosensing, diagnosis, theranostics, tissue engineering and regenerative medicine

Description of learning outcomes for module
MLO code Student after module completion has the knowledge/ knows how to/is able to Connections with FLO Method of learning outcomes verification (form of completion)
Social competence
M_K001 Student can work in a team and discuss the impact of nanotechnology on medicine and healthcare in a clear and comprehensive way IB1A_K03 Presentation
M_K002 Student is aware of risk and fate of nanoparticles and necessity of taking responsible decisions IB1A_K02 Presentation
Skills
M_U001 Student can propose methods to characterize structure and properties of nanoparticles IB1A_U01, IB1A_U08 Activity during classes
M_U002 Student can propose how to manufacture nanoparticles for drug delivery and bioimaging IB1A_U08 Activity during classes
Knowledge
M_W001 Student knows what is the application of nanoparticles in drug delivery, biosensing, diagnosis, theranostic and regenerative medicine IB1A_W03, IB1A_W12, IB1A_W06 Test
M_W002 Student knows recent research advances in nanomedicine IB1A_W03, IB1A_W12 Test
M_W003 Student understands basic molecular mechanisms underlying action of nanoparticles in cells and tissues IB1A_W12, IB1A_W05 Test
FLO matrix in relation to forms of classes
MLO code Student after module completion has the knowledge/ knows how to/is able to Form of classes
Lecture
Audit. classes
Lab. classes
Project classes
Conv. seminar
Seminar classes
Pract. classes
Zaj. terenowe
Zaj. warsztatowe
Others
E-learning
Social competence
M_K001 Student can work in a team and discuss the impact of nanotechnology on medicine and healthcare in a clear and comprehensive way - - + - - + - - - - -
M_K002 Student is aware of risk and fate of nanoparticles and necessity of taking responsible decisions + - + - - + - - - - -
Skills
M_U001 Student can propose methods to characterize structure and properties of nanoparticles - - + - - + - - - - -
M_U002 Student can propose how to manufacture nanoparticles for drug delivery and bioimaging + - - - - + - - - - -
Knowledge
M_W001 Student knows what is the application of nanoparticles in drug delivery, biosensing, diagnosis, theranostic and regenerative medicine + - - - - - - - - - -
M_W002 Student knows recent research advances in nanomedicine + - - - - - - - - - -
M_W003 Student understands basic molecular mechanisms underlying action of nanoparticles in cells and tissues + - - - - - - - - - -
Module content
Lectures:

1. Nanomedicine: hype or hope?
2. Pharmacokinetics and biodistribution of nanoparticles
3. Safety, risk and fate of nanoparticles
4. Nanotechnology and nanoparticles for therapy and drug delivery
5. Nanoradiopharmaceuticals
6. Polymer nanoparticles and drug-polymer conjugates
7. Smart, stimuli-responsive drug delivery systems
8. Engineered nanoparticles for bioimaging and theranostics
9. Nanobiosensors and microfluidics
10. Biology-inspired nanostructures
11. Nanobiomaterials for regenerative medicine
12. Cell and gene therapies with the use of nanovectors
13. Clinical translation and commercialization of nanomedicine products
14. Ethical, social and business considerations for nanomedicine

Laboratory classes:

1. Manufacturing of polymer and lipid nanoparticles for carriers of drugs and/or biologically active molecules
2. Characterization of size and topography of drug delivery systems by atomic force microscopy
3. Manufacturing of silver nanoparticles by chemical reduction method
4. Evaluation of drug loading efficiency in nanoparticles
5. Evaluation of nanoparticles endocytosis by cells in culture

Seminar classes:

Nanoparticles as carriers of drugs, genes and biologically active molecules (nanospheres, micelles, liposomes, dendrimers, polymer-drug conjugates) – preparation techniques, properties, applications
Nanomaterials for nanomedicine and theranostics (superparamagnetic nanoparticles, gold nanoparticles, silver nanoparticles, ceramic nanoparticles, quantum dots) – preparation techniques, properties, applications

Student workload (ECTS credits balance)
Student activity form Student workload
Summary student workload 86 h
Module ECTS credits 3 ECTS
Participation in lectures 28 h
Participation in seminar classes 14 h
Participation in laboratory classes 14 h
Preparation of a report, presentation, written work, etc. 15 h
Preparation for classes 5 h
Realization of independently performed tasks 7 h
Contact hours 2 h
Examination or Final test 1 h
Additional information
Method of calculating the final grade:

33.3% – seminars grade
33.3% – laboratories grade
33.3% – test grade
Further details will be given during the first meeting.

Prerequisites and additional requirements:

Basic knowledge in chemistry, physics, materials science and biology

Recommended literature and teaching resources:

1. Ezharul Hoque Chowdhury, Nanotherapeutics: From Laboratory to Clinic, CRC Press, 2016
2. Jose L. Arias, Nanotechnology and Drug Delivery, Volume Two: Nano-Engineering Strategies and Nanomedicines against Severe Diseases, CRC Press, 2016
3. Ketul Popat, Nanotechnology in tissue engineering and regenerative medicine¸ CRC Press, 2011
4. Thomas J. Webster, Safety of nanoparticles, Springer, 2009
5. Manuals for laboratory classes and recent publications provided by the teachers

Scientific publications of module course instructors related to the topic of the module:

1. U. Posadowska, M. Parizek, E. Filova, M. Włodarczyk-Biegun, M. Kamperman, L. Bacakova, E. Pamuła. Injectable nanoparticle-loaded hydrogel system for local delivery of sodium alendronate, INTERNATIONAL JOURNAL OF PHARMACEUTICS 485;2015:31-40
2. U. Posadowska, M. Brzychczy-Włoch, A. Drożdż, M. Krok-Borkowicz, M. Włodarczyk-Biegun, P. Dobrzyński, W. Chrzanowski, E. Pamuła. Injectable hybrid delivery system composed of gellan gum, nanoparticles and gentamicin for the localized treatment of bone infections. EXPERT OPINION ON DRUG DELIVERY 13;2016:613-620
3. L. Rumian, H. Tiainen, U. Cibor, M. Krok-Borkowicz, M. Brzychczy-Włoch, H. Haugen, E. Pamuła. Ceramic scaffolds enriched with gentamicin loaded poly(lactide-co-glycolide) microparticles for prevention and treatment of bone tissue infections MATERIALS SCIENCE & ENGINEERING C – MATERIALS FOR BIOLOGICAL APPLICATIONS 69;2016:856-864

Additional information:

None