Module also offered within study programmes:
Code Study programme
CCER-2-313-CT-s Ceramics (Ceramika techniczna i konstrukcyjna) - full-time studies second-cycle studies
CTCH-2-319-AK-s Chemical Technology (Analityka i kontrola jakości) - full-time studies second-cycle studies
CCER-1-014-s Ceramics - full-time studies first-cycle studies
CIMT-2-313-MN-s Materials Science (Zaawansowane Materiały Ceramiczne) - full-time studies second-cycle studies
CCER-2-313-MK-s Ceramics (Materiały dla konserwacji i rewitalizacji) - full-time studies second-cycle studies
CIMT-2-312-MF-s Materials Science (Materiały funkcjonalne) - full-time studies second-cycle studies
CIMT-2-408-MF-s Materials Science - full-time studies second-cycle studies
CTCH-2-309-AK-s Chemical Technology (Analityka i kontrola jakości) - full-time studies second-cycle studies
CIMT-1-018-s Materials Science - full-time studies first-cycle studies
CTCH-2-407-AK-s Chemical Technology - full-time studies second-cycle studies
CCER-2-313-WC-s Ceramics - full-time studies second-cycle studies
CIMT-2-312-BK-s Materials Science - full-time studies second-cycle studies
CTCH-2-314-TS-s Chemical Technology - full-time studies second-cycle studies
CTCH-2-315-TM-s Chemical Technology (Technologia materiałów budowlanych) - full-time studies second-cycle studies
CCHB-1-009-s Chemistry of Building Materials - full-time studies first-cycle studies
CTCH-2-307-TC-s Chemical Technology (Technologia ceramiki i materiałów ogniotrwałych) - full-time studies second-cycle studies
CIMT-2-312-FM-s Materials Science (Functional Materials) - full-time studies second-cycle studies
General information:
Name:
BioSurface Engineering
Course of study:
2019/2020
Code:
CTCH-2-314-TS-s
Faculty of:
Materials Science and Ceramics
Study level:
Second-cycle studies
Specialty:
-
Field of study:
Chemical Technology
Semester:
3
Profile of education:
Academic (A)
Lecture language:
English
Form and type of study:
Full-time studies
Course homepage:
 
Responsible teacher:
prof. dr hab. inż. Pamuła Elżbieta (epamula@agh.edu.pl)
Module summary

The students are introduced to different methods of a defined design of biomaterials surface properties taking into account biological phenomena and available manufacturing methods.

Description of learning outcomes for module
MLO code Student after module completion has the knowledge/ knows how to/is able to Connections with FLO Method of learning outcomes verification (form of completion)
Social competence: is able to
M_K001 Is able to work in a team and communicate pieces of information on biosurface engineering in a clear and comprehensive way Presentation
Skills: he can
M_U001 Is able to propose modification method of different biomaterials for use in contact with different tissues Presentation
M_U002 Knows the principles of immobilization of biologically active molecules on biomaterials’ surface Presentation
Knowledge: he knows and understands
M_W001 Knows how surface chemistry, topography as well as mechanical and physical factors influence cellular response Test
M_W002 Knows different methods for a defined design of biomaterials’ surface properties Test
Number of hours for each form of classes:
Sum (hours)
Lecture
Audit. classes
Lab. classes
Project classes
Conv. seminar
Seminar classes
Pract. classes
Zaj. terenowe
Zaj. warsztatowe
Prace kontr. przejść.
Lektorat
30 0 0 0 0 0 30 0 0 0 0 0
FLO matrix in relation to forms of classes
MLO code Student after module completion has the knowledge/ knows how to/is able to Form of classes
Lecture
Audit. classes
Lab. classes
Project classes
Conv. seminar
Seminar classes
Pract. classes
Zaj. terenowe
Zaj. warsztatowe
Prace kontr. przejść.
Lektorat
Social competence
M_K001 Is able to work in a team and communicate pieces of information on biosurface engineering in a clear and comprehensive way - - - - - + - - - - -
Skills
M_U001 Is able to propose modification method of different biomaterials for use in contact with different tissues - - - - - + - - - - -
M_U002 Knows the principles of immobilization of biologically active molecules on biomaterials’ surface - - - - - + - - - - -
Knowledge
M_W001 Knows how surface chemistry, topography as well as mechanical and physical factors influence cellular response - - - - - + - - - - -
M_W002 Knows different methods for a defined design of biomaterials’ surface properties - - - - - + - - - - -
Student workload (ECTS credits balance)
Student activity form Student workload
Summary student workload 80 h
Module ECTS credits 3 ECTS
Udział w zajęciach dydaktycznych/praktyka 30 h
Preparation for classes 10 h
przygotowanie projektu, prezentacji, pracy pisemnej, sprawozdania 20 h
Realization of independently performed tasks 20 h
Module content
Seminar classes (30h):

The course aims to introduce to the students different methods for a defined design of biomaterials surface properties with special attention paid to
● the biological background,
● the methods to generate the surface property profile,
● the biologically wanted surface property as well as
● relevant results from cell biological experiments, animal testing, and clinical trials.
This includes (i) methods to create defined surface morphologies via physical and chemical processing, (ii) physical and chemical modifications of surface properties, (iii) inorganic coating systems, and (iv) the whole area of BioSurface Engineering, i.e. the biomimetic imitation of the native cellular microenvironment given by the properties of the native extracellular matrix (ECM).
This will enable students to design biomaterials surfaces from various substrates for biomedical applications in different areas such as tissue engineering and regenerative medicine for use in contact with different tissues.
Topics:
1. Biofunctionality, cell communication and surfaces
2. Surface morphology and cellular response
3. Physico-chemical surface properties and cellular response
4. Mechanical and physical factors influencing cellular response
5. Introduction to BioSurface Engineering
6. Strategies for immobilization I
7. Strategies for immobilization II
8. Peptides
9. Components of the extracellular matrix
10. Growth factors and cytokines

Additional information
Teaching methods and techniques:
  • Seminar classes: Na zajęciach seminaryjnych podstawą jest prezentacja multimedialna oraz ustna prowadzona przez studentów. Kolejnym ważnym elementem kształcenia są odpowiedzi na powstałe pytania, a także dyskusja studentów nad prezentowanymi treściami.
Warunki i sposób zaliczenia poszczególnych form zajęć, w tym zasady zaliczeń poprawkowych, a także warunki dopuszczenia do egzaminu:

Positive marks from tests and presentation

Participation rules in classes:
  • Seminar classes:
    – Attendance is mandatory: Yes
    – Participation rules in classes: Studenci prezentują na forum grupy temat wskazany przez prowadzącego oraz uczestniczą w dyskusji nad tym tematem. Ocenie podlega zarówno wartość merytoryczna prezentacji, jak i tzw. kompetencje miękkie.
Method of calculating the final grade:

The algorithm of the final mark calculation: test 1 (1/3), test 2 (1/3), presentation
(1/3)

Sposób i tryb wyrównywania zaległości powstałych wskutek nieobecności studenta na zajęciach:

In case of an absence from the seminar classes immediately contact the teacher.

Prerequisites and additional requirements:

Basic course of chemistry, physics, materials science, knowledge of English

Recommended literature and teaching resources:

Biomaterials Science, Edited by Ratner et al., Elsevier, 2012.
Titanium in Medicine, Edited by Brunette et al., Springer, 2001.
Molecular Biology of the Cell, Edited by Alberts et al., Taylor & Francis, 2004.

Scientific publications of module course instructors related to the topic of the module:

1. Wojak-Ćwik, I.M., Rumian, Ł., Krok-Borkowicz, M., [et al.], Scharnweber, D., Pamuła, E. Synergistic effect of bimodal pore distribution and artificial extracellular matrices in polymeric scaffolds on osteogenic differentiation of human mesenchymal stem cells Materials Science and Engineering C 97, 2019, 12-22.
2. Małgorzata Krok-Borkowicz, Elena Filova, Jaroslav Chlupac, Jan Klepetar, Lucie Bacakova, Elżbieta Pamuła, Influence of pore size and hydroxyapatite deposition in poly(l-lactide-co-glycolide) scaffolds on osteoblast-like cells cultured in static and dynamic conditions, Materials Letters 241, 2019, 1-5.
3. Ł. Rumian, H. Tiainen, U. Cibor, M. Krok-Borkowicz, M. Brzychczy-Włoch, H. J. Haugen, E. Pamula, Ceramic scaffolds with immobilized vancomycin-loaded poly(lactide-co-glycolide) microparticles for bone defects treatment, Materials Letters 190, 2017, 67-70.
4. T. E. L. Douglas, G. Krawczyk, E. Pamula, [et al.], Generation of composites for bone tissue-enginnering applications consisting of gellan gum hydrogels mineralized with calcium and magnesium phosphate phases by enzymatic means, Journal of Tissue Engineering and Regenerative Medicine 10(11), 2016, 938–954.

Additional information:

None